Pan Huaqi, Male, born in June 1982 in Tianshui, Gansu Province. PhD, Professor, Principal Investigator (PI) of the Agricultural Microbiology and Synthetic Biotechnology Group, Institute of Applied Ecology, Chinese Academy of Sciences (CAS). Concurrently serves as Director of Liaoning Engineering Research Center for Agricultural Microbial Intelligent Manufacturing, Vice Chairman of the Industrial Technology Innovation Alliance for Biopesticides and Biological Control, Member of the Professional Committee on General Microbiology of the Chinese Society for Microbiology, Vice Chairman of Liaoning Society for Microbiology, and Master Supervisor at Shenyang Pharmaceutical University. He is also an Editorial Board Member of the Chinese Journal of Applied Ecology and a Young Editorial Board Member of the Chinese Journal of Antibiotics. His research interests using an interdisciplinary approach to study special econiche microbes and their bioactive molecules as well as drug development (especially biopesticides), with main research directions as follows: (1) Efficient mining of functional microorganisms and construction of synthetic microbial consortia; (2) Discovery of novel bioactive natural products based on the SPLSD strategy; (3) Natural product metabolic engineering and construction of microbial cell factories; (4) Biopesticide discovery and development.

2010.09 – 2013.12, Ph.D., Medicinal Chemistry of Natural Products, Shenyang Pharmaceutical University 2004.09 – 2007.06, M.S., Microbiology and Immunology, Gansu Agricultural University & Nanjing Agricultural University 2001.09 – 2004.06, B.S., Veterinary Medicine, Gansu Agricultural University

2021.12 – Present, Professor / Principal Investigator, Institute of Applied Ecology, CAS 2015.12 – 2021.11, Associate Professor, Institute of Applied Ecology, CAS 2015.09 – 2016.12, Visiting Researcher, South China Sea Institute of Oceanology, CAS 2007.07 – 2015.11, Research Assistant / Assistant Professor, Institute of Applied Ecology, CAS

Synthetic microbial consortia, Lead compounds, Secondary metabolism, Metabolic engineering, Biopesticides

1. 2025 First Prize of the Ministry of Natural Resources "2024 Science and Technology Progress Award" (4/12) 2. 2023 Excellent Member of Youth Innovation Promotion Association, CAS (1/1) 3. 2023 Leading Talent of Shenyang City (1/1) 4. 2018 Young Top Talent of Liaoning "Xingliao Talents Program" (1/1) 5. 2018 Thousand-Level Candidate of Liaoning "Hundred-Thousand-Ten Thousand Talents Project" (1/1)

1. 2023–2028: Project Leader, Discovery and utilization of novel microbial biochemical inhibitors, National Key R&D Program 2. 2023–2028: Project Leader, R&D and application of multifunctional microbial inoculants for diversified cropping systems, National Key R&D Program 3. 2023–2028: Subproject Leader, Mining of novel agricultural natural products from marine microorganisms and their biosynthesis, National Natural Science 4. 2022–2024: Project Leader, High-yield production of bafilomycins in marine Streptomyces via synthetic biology engineering, Liaoning Applied Basic Research Program 5. 2019–2022: Project Leader, Regulatory mechanism and high-yield research of agricultural antibiotic bafilomycins synthesized by Streptomyces cavourensis, National Natural Science Foundation of China 6. 2016–2019: Project Leader, Rapid discovery of marine microorganisms producing novel secondary metabolites and agricultural antibiotics, National Natural Science Foundation of China

1. Bai Yan†, Tan Meiyan†, Sun Hailiang, Wang Xiaoke, Song Xiaoyu, Hu Jiangchun, Pan Huaqi*. 2026. Azaspiromycin and pentalenolactone derivatives with insecticidal activities against Plutella xylostella from Streptomyces huasconensis NA10. Pest Management Science, DOI:10.1002/ps.70751 2. Song Xiaoyu, Zhang Wenkun, Bai Yan, Zhang Lili, Hu Jiangchun, Wu Zhijie, Pan Huaqi*. 2026. Comprehensive review and outlook of the synthetic urease inhibitors for agricultural applications. Journal of Agricultural and Food Chemistry, https://doi.org/10.1021/acs.jafc.5c16741 3. Bai Yan†, Gao Weixian†, Zhao Wendian, Hu Jiangchun, Pan Huaqi*. 2026. Genome mining and molecular networking targeted discovery of siderophores with plant growth-promoting activities from Streptomonospora nanhaiensis 12A09T. Marine Drugs 24(1): 7. 4. Bai Yan†, Kong Fengting†, Song Xiaoyu, Han Yafei, Jiang, Yinzhou, Hu Jiangchun, Pan Huaqi*. 2025. Indole-diterpenoids from an endophytic Penicillium brefeldianum F4a and their antifeedant and insecticidal activities against Spodoptera frugiperda, Pest Management Science 81: 4788–4798 5. Lei Piao†, JiangYinzhou†, Bai Yan, Hu Jiangchun, Pan Huaqi*. 2025. Bacillus velezensis 9912 enhances rice growth by triggering plant hormone modulation and complex miRNA-mRNA regulatory networks. bioRxiv doi: https://doi.org/10.1101/2025.03.06.641824 6. Ni Zijun, Zhang Xiaorong, Jia Chunyun, Hashmi Muhammad Zaffar , Guo Shuhai , Pan Huaqi*, Gong Zongqiang*. 2025. Winter bioaugmentation of co-contaminated soil: Differential effects in greenhouse and open-field settings on microbial communities. Applied Soil Ecology 215:106446 7. Bai Yan, Ma Xiaodong, Ren Duo, Yu Guoqing, Hu Jiangchun, Hua Huiming, Pan Huaqi*. 2024. Peniapyrones A−I, cytotoxic tricyclic-fused α‑pyrone derivatives from an endophytic Penicillium brefeldianum F4a，Journal of Natural Products 87(6): 1643–1651. 8. Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Hu Jiangchun, Pan Huaqi*. 2024. Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Arabian Journal of Chemistry 17: 105388. 9. Yan Bai, Duo Ren, Fenglin Li, Hu Jiangchun, Pan Huaqi*. 2023. Genome mining and molecular networking guided isolation of antimycin analogs with antifeedant activities from the deep-sea-derived Streptomyces sp. NA13. Chemistry & Biodiversity 20: e202300715. 10. Yan Bai, Ping Yi, Fenglin Li, Hu Jiangchun, Pan Huaqi*. 2022. Penipentenone A and brefeldin A derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a. Phytochemistry 200: 113243. 11. Bai Yan, Yi Ping, Zhang Yun, Hu Jiangchun, Wang Ying, Ju Jianhua, Pan Huaqi*. 2021. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the marine-derived Streptomyces sp. 18A01. Journal of Antibiotic 74: 799–806 (Cover story) 12. Pan Hua-Qi, Tian Xin-Peng, Shao Ming-Wei, Xie Yun-Chang, Huang Hong-Bo, Hu Jiang-Chun, Ju Jian-Hua*. 2019. Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746. Applied Microbiology and Biotechnology 103(10): 4153–4165. 13. Han Tong#, Tian Kang-Tao#, Pan Hua-Qi#, Liu Yong-Xiang, Xu Fan-Xing, Li Zhan-Lin, Uchita Takahiro, Gao Ming, Hua Hui-Ming, Li Da-Hong*. 2018. Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. European Journal of Medicinal Chemistry 150: 53–63. 14. Tian Kang-Tao#, Xu Fan-Xing#, Gao Xiang, Han Tong, Li Jia, Pan Hua-Qi*, Zang Ling-He, Li Da-Hong*, Li Zhan-Lin, Uchita Takahiro, Gao Ming, Hua Hui-Ming*. 2017. Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents. European Journal of Medicinal Chemistry 136:131–143. 15. Pan Hua-Qi, Li Qing-Lian, Hu Jiang-Chun*. 2017. The complete genome sequence of Bacillus velezensis 9912D reveals its biocontrol mechanism as a novel commercial biological fungicide agent. Journal of Biotechnology 247: 25–28. 16. Pan Hua-Qi, Cheng Juan, Zhang Dao-Feng, Yu Su-Ya, Khieu Thi-Nhan, Son Chu Ky, Jiang Zhao, Hu Jiang-Chun*, Li Wen-Jun*. 2015. Streptomyces bohaiensis sp. nov., a novel actinomycete isolated from Scomberomorus niphonius in the Bohai Sea. Journal of Antibiotics 68 (4): 246–252. 17. Pan Hua-Qi #, Zhang Dao-Feng#, Li Li, Jiang Zhao, Cheng Juan, Zhang Yong-Guang, Wang Hong-Fei, Hu Jiang-Chun*, Li Wen-Jun*. 2015. Nocardiopsis oceani sp. nov. and Nocardiopsis nanhaiensis sp. nov., two novel actinomycete isolated from marine sediment of South China Sea, International Journal of Systematic and Evolutionary Microbiology 65: 3384–3391. 18. Pan, Hua-Qi, Zhang Song-Ya, Wang Nan, Li Zhan-Lin, Hua Hui-Ming, Hu Jiang-Chun*, Wang, Shu-Jin. 2013. New spirotetronate antibiotics, lobophorins H and I, from a South China Sea-derived Streptomyces sp. 12A35. Marine Drugs 11: 3891–3901. 19. Pan Hua-Qi, Wang Nan, Liu Lie, Liu, Li, Hu Jiang-Chun, Chen Pu-Yan, Wang Shu-Jin, Cao Rui-Bing*. 2009. Molecular characterization of the duck enteritis virus UL4 gene. Virologica Sinica 24: 171–178. 20. Pan Hua-Qi, Cao Rui-Bing*, Liu Lie, Niu Ming-Fu, Zhou Bin, Chen Pu-Yan, Hu Jiang-Chun. 2008. Molecular cloning and sequence analysis of the duck enteritis virus UL5 gene. Virus research 136: 152–156.

1. Pan Huaqi, et al. Deep-sea Streptomyces strain, preparation, and application of its antifeedant and antifungal active substances. Authorized date: 2026-03-09, Application No.: ZL202211283332.6 2. Pan Huaqi, et al. Preparation method and application of an indole diterpenoid compound. Authorized date: 2025-11-13, ApplicationNo.: ZL202410949705.1 3. Pan Huaqi, et al. A disease-resistant, growth-promoting, and yield-increasing strain, and its composite microbial inoculant and application thereof. Authorized date: 2025-07-08, Application No.: ZL202510362154.3 4. Pan Huaqi, et al. A novel tricyclic fused pyranone compound, its preparation method and use. Authorized date: 2025-09-12, Application No.: ZL202410163014.9 5. Pan Huaqi, et al. A siderophore compound, its preparation and application. Authorized date: 2025-09-23, Application No.: ZL202411526973.9 6. Pan Huaqi, et al. A bioactive secondary metabolite, its preparation and application. Authorized date: 2023-06-16, Application No.: ZL202111001911.2 7. Pan Huaqi, et al. A sponge-derived Streptomyces strain and preparation and application of its hexokinase II inhibitory substance. Authorized date: 2022-07-05, Application No.: ZL202011604925.9 8. Pan Huaqi, et al. An Actinoalloteichus strain, preparation and application of its antimicrobial and antitumor active substances. Authorized date: 2021-11-16, Application No.: ZL201811623157.4 9. Pan Huaqi, et al. An Actinoalloteichus strain, three novel antifungal maclafungins and their preparation and application. Authorized date: 2018-05-25, Application No.: ZL201410072940.1 10. Pan Huaqi, et al. An endophytic fungus Eupenicillium brefeldianum F4a and application thereof. Authorized date: 2017-12-19, Application No.: ZL201410072690.1 11. Pan Huaqi, et al. A Streptomyces strain, spirotetronate compounds produced thereby, preparation and application thereof. Authorized date: 2015-06-24, Application No.: ZL201310145450.5 12. Pan Huaqi, et al. A spore-producing medium, its optimization process and application. Authorized date: 2014-09-03, Application No.: ZL201010614523.7